Disease-Specific Working Groups

Disease-Specific Working Groups

Defining what matters most within each condition
OMERACT Disease-Specific Working Groups focus on developing Core Outcome Sets (COS) for individual diseases or anatomical areas.
Each group brings together clinicians, researchers, and patient research partners (PRPs) to identify what should be measured in clinical trials, how best to measure it, and how to ensure those outcomes are relevant, feasible, and meaningful to both science and patients.
These groups follow OMERACT’s structured pathway from identifying unmet measurement needs to gaining international consensus and endorsement ensuring every Core Outcome Set meets the OMERACT Filter standards of truth, discrimination, and feasibility.
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Click on a group below to learn more about their goals, progress, and contributions and find out how you can get involved.

ANCA-Associated Vasculitis: Developing composite response criteria for vasculitis.
Behçet’s: Selecting instruments to measure disease activity across organ systems.
Calcium Pyrophosphate Deposition (CPPD): Endorsement for Core Domain Sets.
Chronic Nonbacterial Osteomyelitis (CNO): Developing a Core Domain Set.
Flares in Osteoarthritis (OA): Developing a composite to capture flare in OA and their life impact.
Foot & Ankle Disorders: Creating a Core Domain Set for trials of foot and ankle disorders.
Gout: Providing guidance on measurement and reporting standards for the gout Core Outcome Set.
Hip and Knee Osteoarthritis(OA): Selecting instruments that best represent the Core Domains.
Juvenile Idiopathic Arthritis(JIA): Selecting instruments to measure overall well-being in children with JIA.
Large-Vessel Vasculitis: Revising a damage index for giant cell arteritis and Takayasu arteritis.
Late Stage Knee & Hip OA: Identifying core domains to define and measure progression in late-stage osteoarthritis
Myositis: Identifying patient-reported outcomes that capture the multidimensional impact of myositis.
Patient Outcomes in Longitudinal Observational Studies (POLOS)-RA: Finalizing Core Domain Set.
Polymyalgia Rheumatica (PMR): Advancing instrument selection for Core Domains.
Psoriatic Arthritis (PsA): Refining and validating composite measures for Psoriatic Arthritis.
Rheumatoid Arthritis: Maintaining the globally endorsed Core Outcome Set for Rheumatoid Arthritis clinical trials.
Scleroderma Vascular Disease: Selecting instruments for raynaud’s phenomenon and digital ulcers.
Shoulder Disorders: Evaluating pain and function instruments for inclusion in a Core Outcome Set.
Sjögren’s Disease: Launching Delphi to prioritize domains for the Core Domain Set.
Systemic Lupus Erythematosus (SLE): Conducting multilingual Delphi studies to finalize the Core Domain Set.

New to OMERACT?

OMERACT Working Groups follow a structured, consensus-driven approach to developing Core Outcome Sets. Explore how this process unfolds and discover more about how OMERACT advances outcome measurement in rheumatology.

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