Core Outcome Sets – OMERACT

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What is a Core Outcome Set (COS)?

A Core Outcome Set (COS) is an agreed minimum set of outcome domains and corresponding measurement instruments that should be measured and reported in all clinical trials or studies for a specific health condition or intervention. These sets ensure consistency, comparability, and relevance of research findings across studies—supporting decision-making by patients, clinicians, regulators, and policymakers.

OMERACT COS are developed using a rigorous, transparent, and consensus-driven process that includes perspectives from researchers, clinicians, methodologists, regulators, and—critically—patient research partners (PRPs). This ensures the outcomes reflect what matters most to those living with the condition.

Explore Published OMERACT Core Outcome Sets

Below is a list of published Core Outcome Sets that have been developed through the OMERACT process.

TABLE 1.1A OMERACT core areas and core domains for joint health conditions

TABLE 1.1B OMERACT core areas and core domains for systemic rheumatologic health conditions