About the Late-stage Knee and Hip Osteoarthritis Composite Measure Working Group
The receipt of a total knee (TKR) or hip replacement (THR) has commonly been used in clinical trials as an outcome measure of “late-stage” osteoarthritis (OA). However, total joint replacement outcomes are highly variable, dependent on a patient’s access and preference for surgery, the surgeon’s preference, socio-economic and geographical factors. There have been calls by the clinical trial community and clinical regulators to define a clinical endpoint for “late stage OA”, leading to the development of a new composite measure that can be used as both an outcome measure or inclusion/exclusion criteria in clinical trials.
The aims of this working group are to generate and define a set of candidate target domains to be included in all studies that aim to prevent or reduce TKR or THR, with a view to future developing a composite measure of the late-stage OA.

Francis Guillemin
Co-Chair

Gillian Hawker
Co-Chair

David Hunter
Co-Chair

Lyn March
Co-Chair

WORKING GROUP PUBLICATIONS
Working Group Members:
Adewale Adebajo
Angie Botto-van Bemden
Aya Akmal Amin
Celeste Scotti
David Hunter
Denise Bury
Esmarie Venier
Fernando Pimentel-Santos
Francis Guillemin
Gehad Maghraby
Gillian Hawker
Ilfita Sahbudin
Illana Ackerman
Jane Stretton
Jean Liew
Jocelyn Bowden
Jurgen Loffler
Lauren King
Lyn March
Marie March
Olufemi Adelowo
Peter Tugwell
Philip Conaghan
Philippa Nicolson
Qiuke Wang
Rashed Toticell
Shawna Grosskleg
Sougata Panda
Tamer Gheita
Toby Smith
Tuhina Neogi
Win Min Oo
Yari Nickolic