A Cochrane Review is a systematic, up-to-date summary of reliable evidence of the benefits and risks of healthcare. Cochrane Reviews are intended to help people make practical decisions. For a review to be called a “Cochrane Review” it must be in the database maintained by Cochrane, the Cochrane Database of Systematic Reviews. . . Cochrane Reviews are prepared by authors who register titles with one of the Cochrane Review Groups (CRG). Each Cochrane Review Group focuses on a specific topic area and provide authors with methodological and editorial support to prepare Cochrane Reviews, and manage the editorial process, including peer review. Review authors adhere to guidelines published in the Cochrane Handbook for Systematic Reviews of Interventions. The specific methods used in a Review are described in the text of the review. Cochrane Reviews are prepared using Review Manager software provided by the Cochrane.