About the Juvenile Idiopathic Arthritis Magnetic Resonance Imaging (JAMRI) Working Group
About the Juvenile Idiopathic Arthritis Magnetic Resonance Imaging (JAMRI) Working Group Juvenile Idiopathic arthritis (JIA) is a chronic inflammatory disease that affect joint function, resulting in significant effect on quality of life by limited physical and psychosocial integration. JIA has an estimated worldwide prevalence of 0.07 to 4.01 cases and an incidence rate of 0.008 to 0.226 cases per 1000 children per year, respectively, highlighting the global disease burden and the need for new clinical trials for JIA management.
Magnetic resonance imaging (MRI) is the reference imaging modality for joints in JIA, because it has reported to be sensitive in detecting early inflammatory changes in sacroiliac joints (SIJ) in JIA long before radiography, thus allowing for intervention before the onset of irreversible joint damage. Furthermore, MRI is best suited to evaluate joints which are limited by location and have complex anatomy, making clinical assessment challenging.
As more evidence support the use of imaging as an outcome measure in JIA clinical trials and the inclusion of joint damage and imaging signs of inflammation as part of the JIA core outcome set (COS) in the middle circle of the OMERACT initiative, the JAMRI working group (WG) has been in the forefront of developing and validating pediatric specific joints MRI measurement instruments for use as outcome measure in JIA clinical trials.
The JAMRI working group has three special interest group (SIG); Temporomandibular joint (TMJ), sacroiliac joint (SIJ) and whole-body MRI (WBMRI) Special Interest Groups (SIGs). Through continuous work during over a decade within the respective SIGs, the JAMRI working group has developed the OMERACT Juvenile Idiopathic Arthritis Temporomandibular Joint Score (JAMRIS-TMJ), the Juvenile Idiopathic Arthritis Sacroiliac Joint Score (JAMRIS-SIJ) and the Juvenile Idiopathic Arthritis Whole Body MRI score (JAMRIS-WBMRI). The validation process for MRI measurement instruments for these joints is in different stages of progress.
In the OMERACT meeting to be hold in the spring of 2023 in Colorado Spring, U.S.A., our working group will focus on discussions on the validation process of the SIJ, most specifically on the reliability aspect of the process for the JAMRIS-SIJ. The methodology and results from the validation studies and other imitative in the group will be presented at the OMERACT meeting.
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Andrea Doria
Co-Chair

Marion van Rossum
Co-Chair
Johnathan Akikusa
Co-Chair

Walter Maksymowych
Project Leaders of SIJ Working Group(Reliability 2)
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Arthur Meyers
Project Leaders of SIJ Working Group (Survey)
Working Group Publications
- Otobo, Tarimobo M., Mirkamal Tolend, Arthur B. Meyers, Iwona Sudol-Szopinska, Sayali Joshi, Jennifer Stimec, Nele Herregods, Jacob L. Jaremko, Shirley M. L. Tse, Nigil Haroon, Rahim Moineddin, Nikolay Tzaribachev, Simone Appenzeller, Michal Znajdek, Manuela Perez, Aloysius E. Ligha, Lennart Jans, Emilio J. Inarejos Clemente, Pamela Weiss, Olympia Papakonstantinou, Eva Kirkhus, Marion A. J. van Rossum, Dax G. Rumsey, John Carrino, Jonathan D. Akikusa, Philip G. Conaghan, and Andrea S. Doria. 2023. "Determination of Relative Weightings for Sacroiliac Joint Pathologies in the OMERACT Juvenile Arthritis Magnetic Resonance Imaging Sacroiliac Joint Score" Journal of Clinical Medicine 12, no. 7: 2729. https://doi.org/10.3390/jcm12072729
- Otobo TM, Conaghan PG, Maksymowych WP, van der Heijde D, Weiss P, Sudol-Szopinska I, Herregods N, Jaremko JL, Meyers AB, Rumsey D, Inarejos EC, Kirkhus E, Stimec J, Panwar J, Thorpe K, Jans L, van Rossum MA, Tolend M, Perez M, Tzaribachev N, Sandhya P, Tse S, Simone A, Swami VG, Touma Z, Lambert R, Doria AS. Preliminary Definitions for Sacroiliac Joint Pathologies in the OMERACT Juvenile Idiopathic Arthritis Magnetic Resonance Imaging Score (OMERACT JAMRIS-SIJ). J Rheumatol. 2019 Sep;46(9):1192-1197. doi: 10.3899/jrheum.181115. Epub 2019 Feb 15. PMID: 30770500.
- JAMRI Working Group Publication Updates 1. Otobo, T.M.; Herregods, N.; Jaremko, J.L.; Sudol-Szopinska, I.; Maksymowych, W.P.; Meyers, A.B.; Weiss, P.; Tse, S.; Paschke, J.; Moineddin, R.; Haroon, N.; Tzaribachev, N.; Appenzeller, S.; Papakonstantino, O.; Kirkhus, E.; Van Rossume, M.A.J.; Carrino, J.; Conaghan, P.G.; Tolend, M.; Stimec, J.; Jans, Lennart.; Lambert, R.G.; Rumsey, D.; Doria, A.S. Reliability of the Preliminary OMERACT Juvenile Idiopathic Arthritis MRI Score (OMERACT JAMRIS-SIJ). Journal of Clinical Medicine 2021, 10, 4564.
- Herregods, N.; Maksymowych, W.P.; Jans, L.; Otobo, T.M.; Sudoł-Szopińska, I.; Meyers, A.B.; Van Rossum, M.; Kirkhus, E.; Panwar, J.; Appenzeller, S.; et al. Atlas of MRI findings of sacroiliitis in pediatric sacroiliac joints to accompany the updated preliminary OMERACT pediatric JAMRIS (Juvenile Idiopathic Arthritis MRI Score) scoring system: Part I: Active lesions. Semin Arthritis Rheum 2021, 51, 1089 -1098, doi:10.1016/j.semarthrit. 2021. 07.003.
- Herregods, N.; Maksymowych, W.P.; Jans, L.; Otobo, T.M.; Sudoł-Szopińska, I.; Meyers, A.B.; Van Rossum, M.; Kirkhus, E.; Panwar, J.; Appenzeller, S.; et al. Atlas of MRI findings of sacroiliitis in pediatric sacroiliac joints to accompany the updated preliminary OMERACT pediatric JAMRIS (Juvenile Idiopathic Arthritis MRI Score) scoring system: Part II: Structural damage lesions. Semin Arthritis Rheum 2021, 51,1099-107, doi:10.1016/j. semarthrit. 2021.07.009.
- Malattia C., Tolend M., Marta M., Panwar J., Zlotnik M., Otobo TM, Vidarsson L, and Doria AS (2020): Current Status of Magnetic Resonance Imaging of Juvenile Idiopathic Arthritis. Best Pract Res Clin Rheumatol. 2020 Dec. 34 (6):101629.
- Mirkamal Tolend, Andrea S. Doria, Arthur B. Meyers, Tore A. Larheim, Shelly Abramowicz, Julien Aguet, Simone Appenzeller, Linda Z. Arvidsson, Lauren W. Averill, Brian M. Feldman, Saurabh Guleria, Emilio J. Inarejos Clemente, Jacob L. Jaremko, Thitiporn Junhasavasdikul, Thekla von Kalle, Eva Kirkhus, Bernd Koos, Elka Miller, Rahim Moineddin, Jyoti Panwar, Zachary S. Peacock, Cory M. Resnick, Marion A. van Rossum, Jennifer Stimec, George Tomlinson, Nikolay Tzaribachev, and Christian J. Kellenberger. “Assessing the Reliability of the OMERACT Juvenile Idiopathic Arthritis Magnetic Resonance Scoring System for Temporomandibular Joints (JAMRISTMJ).” Journal of Clinical Medicine. 2021 Sep;10(18):4047.
- Jyoti Panwar, Mirkamal Tolend, Bernadette Redd, Hemalatha Srinivasalu, Robert A. Colbert, Jonathan Akikusa, Simone Appenzeller, John A. Carrino, Nele Herregods, Lennart Jans, Kerri Highmore, Thekla von Kalle, Eva Kirkhus, Dax G. Rumsey, Jacob L. Jaremko, Inarejos Emilio J. Clemente, Marion A. van Rossum, Jennifer Stimec, Shirley M. Tse, Marinka Twilt, Nikolay Tzaribachev, Iwona Sudol-Szopinska, Arthur B. Meyers, and Andrea S. Doria. “Consensus-Driven Conceptual Development of a Standardized Whole Body-MRI Scoring System for Assessment of Disease Activity in Juvenile Idiopathic Arthritis: MRI in JIA OMERACT Working Group.” Seminars in Arthritis and Rheumatism. 2021 Dec;51(6):1350-1359.
- Elka Miller, Emilio J. Inarejos Clemente, Nikolay Tzaribachev, Saurabh Guleria, Mirkamal Tolend, Arthur Meyers, Thekla von Kalle, Jennifer Stimec, Bernd Koos, Simone Appenzeller, Linda Z Arvidsson, Eva Kirkhus, Andrea S. Doria, Christian J. Kellenberger, Tore A. Larheim. “Development of a Standardized Magnetic Resonance Imaging Protocol for the Imaging of Temporomandibular Joint Abnormalities in Juvenile Idiopathic Arthritis.” Pediatric Radiology. 2018 Jun;48(6):792-800.
- Mirkamal Tolend, Marinka Twilt, Randy Q. Cron, Nikolay Tzaribachev, Saurabh Guleria, Thekla von Kalle, Bernd Koos, Elka Miller, Jennifer Stimec, Yoginder Vaid, Tore A. Larheim, Troels Herlin, Lynn Spiegel, Emilio Inarejos, Rahim Moineddin, Marion A. van Rossum, Rotraud K. Saurenmann, Andrea S. Doria, Christian J. Kellenberger. “Towards Establishing a Standardized Magnetic Resonance Image Interpretation Protocol for Temporomandibular Joints in Juvenile Idiopathic Arthritis.” Arthritis Care & Research. 2018 May;70(5):758-767.
- Jyoti Panwar, Hiten Patel, Mirkamal Tolend, Jonathan Akikusa, Nele Herregods, Kerri Highmore, Emilio J. Inarejos Clemente, Lennart Jans, Jacob L Jaremko, Thekla von Kalle, Eva Kirkhus, Arthur B. Meyers, Marion van Rossum, Jennifer Stimec, Shirley ML Tse, Marinka Twilt, Nikolay Tzaribachev, Andrea S. Doria. “Toward Developing a Semi-Quantitative Whole-Body MRI Scoring for Juvenile Idiopathic Arthritis: Critical Appraisal of the State of the Art, Challenges and Opportunities.” Academic Radiology. 2021 Feb;28(2):271-286.
- Mirkamal Tolend, Thitiporn Junhasavasdikul, Randy Q. Cron, Emilio J. Inarejos Clemente, Thekla von Kalle, Christian J. Kellenberger, Bernd Koos, Elka Miller, Marion A. van Rossum, Rotraud K. Saurenmann, Lynn Spiegel, Jennifer Stimec, Marinka Twilt, Nikolay Tzaribachev, Shelly Abramowicz, Simone Appenzeller, Linda Z. Arvidsson, Saurabh Guleria, Jacob L. Jaremko, Eva Kirkhus, Tore A. Larheim, Arthur B. Meyers, Jyoti Panwar, Hiten Patel, Cory M. Resnick, Susan C. Shelmerdine, George Tomlinson, Brian M. Feldman, Andrea S. Doria. “Using Discrete Choice Experiment to Determine the Weights of Items and Grades in a Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic Arthritis.” Arthritis Care & Research. 2022 Feb;74(2):308-316.
Working Group Members:
Andrea Doria
Marion van Rossum
Jonathan Akikusa
Vincent del Gaizo
Janet Gunderson
Wendy Olsder
Simon Stones
Tarimobo Otobo
Jyoti Panwar
Jacob Jaremko
Tekla von Kalle
Shirley Tse
Emilio Inarejos
Eva Kirkhus
Simone Appenzeller
Arthur Meyers
Lennart Jans
Hema Srinivasalu
Bernadette Redd
John Carrino
Robert Colbert
Nele Herregods
Kerri Highmore
Dax Rumsey
Jennifer Stimec
Nikolay Tzaribachev
Marinka Tilt
Vimarsha Swami
Robert Lambert
Walter Maksymowych
Jose Dehoorne
Pamela Weiss
Lynn Spiegel
Cory Resnick
Tore Arne Larheim
Robert Hemke
Christian Kellenberger
Bernd Koos
Johannus Roth
Yoginder Vaid
Troels Herlin
Zach Peacock
Traudel Saurenmann
Randy Cron
Saurabh Guleria
Lauren Averill
Elka Miller
Susan Shelmerdine
Linda Z. Arvidsson
Eva Kirkhus
Hiten Patel
Aguet Julien
Maria Navallas Irujo
Jordi Muchart
Brian Feldman
John Carrino
Desiree van der Heijde
Iwona Sudoł-Szopińska
Joel Paschke
Olympia Papakonstantinou
Philip Conaghan
Joshi Sayali
Charlotte Nusman
Berit Flato
Peter Tugwell
Mirkamal Tolend
Roxana Azma
Kerri Highmore
Shelly Abramowicz