About the Gout Working Group
Gout is the most common form of inflammatory arthritis and is caused by deposition of monosodium urate (MSU) crystals in and around joints, which provokes an intense inflammatory response. Gout manifests as episodes of intense joint pain, swelling, and functional disability that may lead to persistent joint symptoms and structural joint damage.
In our pursuit of ensuring that research aligns with the needs and interests of those most affected by gout, our team has diligently worked on the identification and consensus of the most crucial outcomes to be measured in all clinical trials and observational studies of gout.
Our work so far has incorporated key elements of the OMERACT Framework, including a thorough literature review, Delphi surveys, and patient involvement at all stages of the research process. We have developed a Core Domain Set that reflects not only the clinical aspects of gout but also the lived experience of patients.
Building on the progress we've made, our next focus is to provide explicit guidance on the measurement methods and reporting needs for the core outcome set.
Jasvinder A. Singh
Working Group Publications
Outcome Measures for Acute and Chronic Gout
Outcome Evaluations in Gout
Outcome Domains for Studies of Acute and Chronic Gout
Progress in Measurement Instruments for Acute and Chronic Gout Studies
Patient-reported Outcomes in Chronic Gout: A Report from OMERACT 10
Tophus Measurement as an Outcome Measure for Clinical Trials of Chronic Gout: Progress and Research Priorities
Serum Urate in Chronic Gout — Will It Be the First Validated Soluble Biomarker in Rheumatology?
Bringing It All Together: A Novel Approach to the Development of Response Criteria for Chronic Gout Clinical Trials
Outcome Measures in Acute Gout: A Systematic Literature Review
OMERACT Endorsement of Measures of Outcome for Studies of Acute Gout
Application of the OMERACT Filter to Measures of Core Outcome Domains in Recent Clinical Studies of Acute Gout
Imaging as an outcome measure in gout studies: report from the OMERACT gout working group
ENDORSED DOMAINS FOR ACUTE GOUT
ENDORSED DOMAINS FOR CHRONIC GOUT
Working Group Members:
N. Lawrence Edwards
Lee S. Simon
Jasvinder A. Singh
William J. Taylor