About the Adult-onset Still's Disease Working Group
Adult-onset Still´s disease (AOSD) is a rare multisystem inflammatory disorder of unknown etiology, considered as a multigenic autoinflammatory syndrome. AOSD and systemic-onset juvenile idiopathic arthritis are considered a same disease continuum with different ages of onset. AOSD may present distinct clinical evolutions, from monophasic (monocyclic), intermittent to chronic pattern. The classic triad of symptoms is formed by high fever, evanescent rash, and arthritis or arthralgia, other commons manifestations may be present as sore throat, lymphadenopathy, hepatomegaly, serositis and elevated ferritin levels, erythrocyte sedimentation rate and C-reactive protein, leukocytosis, normocytic normochromic anemia and thrombocytosis. Clinical and laboratory findings are not pathognomonic, the diagnosis should be of exclusion. Although uncommon, AOSD may present with serious complications such as macrophage activation syndrome. Currently, there is no universally accepted way of reporting outcomes in studies of this condition.
Working Group Members:
Aya Akmal Amin
Prof. Tamer Gheita
Vani Abreu de Souza Filho