What is a significant difference (improvement or change in disease activity)? It is important to know how many patients actually improved, i.e. is a good group result based on a large number of patients improving moderately, or on a small number of patients with a considerable improvement? In research, statistical tests will show whether a result arose by chance, or whether it is unlikely to have happened by chance and can therefore be said to be significant (eg a statistically significant change in pain on a new drug).

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