An aspect of health or a health condition that needs to be measured to appropriately assess the effects of a health intervention. Areas are broad concepts consisting of a number of more specific concepts called outcome domains. Each area in the framework has a specific role, and together they contain the whole ‘universe’ of concepts that one could conceivably measure to assess the effects of an intervention
There are four “Areas” that should be represented in a Core Outcome Domain Set and ultimately in a Core Outcome Set: manifestations/abnormalities; life impact; societal/resource use; death/lifespan.

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