Pain is a prevailing and common symptom across rheumatic and musculoskeletal diseases (RMD). Clinically, acute and chronic pain are distinct, are managed differently, and have differences in outcomes. The majority of people who experience acute pain tend to improve spontaneously or under treatment, but some individuals progress to a chronic pain that can cause considerable physical, emotional, and socioeconomic burdens. To identify preventive or effectively tailored interventions, standardized pain assessment in clinical trials is essential to making precise estimates on the effectiveness of interventions.