About the Osteoporosis Working Group

The OMERACT Osteoporosis Working Group was established to define and standardize outcome measures for randomized clinical trials (RCTs) in osteoporosis. Given the growing burden of osteoporotic fractures and the wide variability in how clinical trials measure outcomes, OMERACT’s work has been instrumental in guiding consistency, comparability, and improved evidence synthesis in this field.

At OMERACT III (1996), held in Cairns, Australia, experts in rheumatology, endocrinology, radiology, and patient-centered research came together to propose a Core Outcome Set for osteoporosis trials. These recommendations focus on outcomes that are clinically meaningful, sensitive to treatment effects, and feasible to implement across global studies.

OMERACT Endorsed Core Domain Set for use in Clinical Trials/LOS in Osteoporosis

OMERACT Onions with Instruments

WORKING GROUP PUBLICATIONS

  1. Implications of OMERACT Outcomes in Arthritis and Osteoporosis for Cochrane Metaanalysis.

  2. Assessment of Vertebral Fractures in Osteoporosis Research

  3. The Value of Biochemical Markers of Bone Turnover in Osteoporosis

  4. Quality of Life Measurement in Osteoporosis

  5. Osteoporosis Clinical Trials Endpoints Candidate Variables and Clinicmetric Properties

  6. Responsiveness in Endpoints in Osteoporosis Clinical Trials

  7. Guidelines of Osteoporosis Trials

  8. Responsiveness of Endpoints in Osteoporosis Clinical Trials--An Update

  9. Discrimination of Changes in Osteoporosis Outcomes

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