an agreed-upon group of outcome domains considered essential to define and report in all clinical trials and other research studies related to a specific health condition or disease. It represents “what to measure,” not “how to measure it.”

At this stage, no specific instruments have been selected to assess the domains. The CDS is developed through systematic evidence review, input from patients and other stakeholders, and formal consensus methods (e.g., Delphi surveys). Establishing a CDS ensures that the most important aspects of health are consistently captured across studies, improving comparability and relevance.