the observable signs, symptoms, or measurable deviations from normal body functions or structures associated with a health condition. Assessing manifestations or abnormalities is essential for determining whether an intervention specifically targets the underlying pathophysiology of the condition. Within the International Classification of Functioning, Disability and Health (ICF), these correspond to changes in body functions and body structures.
Synonyms: Clinical Signs, Symptoms, Indicators
Example
In rheumatoid arthritis, manifestations/abnormalities include joint swelling, synovial thickening, and reduced grip strength. Evaluating these features allows researchers and clinicians to assess whether a new drug directly improves the disease’s underlying inflammatory processes as reflected in the ICF categories for body functions and structures.